Adoptive T-Cell Therapy
What is Adoptive T-Cell therapy?
Adoptive T-cell therapy is a type of immunotherapy that attempts to boost the natural ability of the patient’s T-cells (killer cells) to fight cancer. T-cells are taken from the tumor, then those that are most active against the tumor are grown in large batches in the lab, engineered to be more resilient and then given back to the patient to help the immune system fight the cancer. The process of growing your T cells in the lab can take 2 to 8 weeks, and during this time, patients may have treatments such as chemotherapy and radiation therapy. After these treatments, the T-cells that were grown in the lab are given back to the patient. This treatment gives the patient’s immune system a better chance to fight the cancer cells and is intended to keep the patient in remission longer.
The idea behind this approach is that the TILs have already shown the ability to target tumor cells, but there may not be enough of them in the tumor microenvironment to kill the tumor or to overcome the immune suppressive signals that the tumor is releasing. Introducing massive amounts of activated TILs can help to overcome these barriers.
How Successful is Adoptive T-Cell Therapy?
Adoptive T-Cell Therapy holds a lot of promise. In a summary of TIL therapy clinical trials, TIL therapy was found to induce complete and durable regression of metastatic melanoma. Tumor reduction of 50% or more was observed in about half of patients. Some patients experienced complete responses with no detectable tumor remaining years after treatment. In one clinical trial, among the 93 patients treated with TILs, 19 patients had complete remissions that lasted greater than 3 years.
Clinical trials using TILs to treat other tumor types, including lung, ovarian, bladder, and breast, are ongoing and promising.
Who is a good candidate?
Clinical trials for a number of tumor types are ongoing in the USA and across the world. Click here to search a complete list.
Adoptive T-Cell therapy requires live cancer cells (tissue or fluid) be preserved at the time of surgery or biopsy and under specific sterile conditions. Live tumor preservation is not routinely done by your hospital. Banking tumor tissue or fluid is an ideal way to test your candidacy for experimental treatments.
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Your tumor is preserved in multiple formats for further study, immediately or at a later time. It is ideal for every cancer patient. Learn more about Tumor Preservation.
Chemo Sensitivity Testing
Tests which chemotheraputic agents will work on the tumor from day one, and and which will not. Learn more about Chemo Sensitivity Testing.
Identifies mutations on your tumor that help your oncologist prescribe more targeted drugs based on your tumor makeup. Learn more about Genomic Profiling.
Tests chemotherapy agents and tens of additional experimental and immunotherapy drugs to find the right combination for a particular tumor. Learn more about Drug Screening.
Immunotherapy designed to treat cancers that have already developed (as opposed to preventative). It educates the immune system to attack your cancer cells. Learn more about Personalized Vaccines.
Adoptive T-Cell Therapy
Immunotherapy approach that attempts to boost the natural ability of the patient’s T-cells (killer cells) to attack and fight yoru cancer cells. Learn more about Adoptive T-Cell Therapy.